MONOCLONAL ANTIBODY TO HUMAN INTERLEUKIN-18, HYBRIDOMA CELL LINE PRODUCING THE SAME, AND PROCESS FOR PRODUCING HYBRIDOMA CELL LINE
摘要
PURPOSE: A monoclonal antibody to human interleukin-18 (IL-18), hybridoma cell line producing the antibody, and a process for producing the hybridoma cell line are provided. Human interleukin-18 induces various inflammations or incurable diseases. CONSTITUTION: Hybridoma cell lines are obtained by fusing a myeloma cell and a mouse spinal cell immunized against human IL-18 or human pro-IL-18. Monoclonal antibodies are massively produced from a hybridoma cell line, which specifically reacts with human IL-18 or human pro-IL-18. A cell expressing IL-18 can be easily detected by using the monoclonal antibody and the hybridoma cell line, thus various inflammations or incurable diseases induced by IL-18 can be diagnosed.
申请公布号
KR20000001629(A)
申请公布日期
2000.01.15
申请号
KR19980021972
申请日期
1998.06.12
申请人
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY.
发明人
YUN, DO YEONG;OH, EUN SUK;YUN, HUI SIK;JO, JEONG WON;KIM, GWANG DONG;LIM, JONG SEOK;CHARLES DINANELO;CHOI, YONG KYEONG;JEONG, TAE HWA;PARK, SUN HUI