METHOD FOR DIAGNOSING AN ADENOCARCINOMA OR A BENIGN PROSTATE PATHOLOGY

摘要

The invention concerns a method for diagnosing a prostate adenocarcinoma in a male human patient without performing prostatic biopsy, using the PSA protein (prostate specific antigen) present in the patient's blood, serum, urine or seminal liquid. The method consists in: a) measuring the free PSA total level, that is cleaved or non-cleaved; b) measuring the level of all or part of the cleaved free PSA; c) calculating the proportion of cleaved free PSA relative to the total free PSA; and d) diagnosing that the patient suffers from: a prostate adenocarcinoma, when said ratio is not more than a reference value; a benign prostate pathology, such as benign prostatic hypretrophy, when said ratio is higher than the reference value. It is also possible to calculate the proportion of non-cleaved free PSA relative to the free PSA total or the proportion of cleaved free PSA relative to the non-cleaved free PSA or to the total PSA or to the complexed PSA or to establish a ratio between those proportions. The invention is applicable to diagnosis of adenocarcinoma or benign prostatic hypertrophy.