摘要 |
<p>The invention concerns peptide derivatives useful as N-terminal site selective inhibitor of the human angiotensin conversion enzyme. Said derivatives comprise the amino acid sequence of the following formula: -Asp-Phe-γ(PO2CH2)-Ala-Xaa'- wherein: γ(PO2CH2) indicates that the peptide bond (CONH) between Phe and Ala has been replaced by the phosphonic bond PO2CH2; and Xaa' represents an amino acid residue. Said derivatives can be used in pharmaceutical compositions, in particular for protecting hematopoietic strain cells of patients subjected to aggressive chemotherapeutic or radiotherapy treatment.</p> |