PROCESS FOR PRODUCING (8- CHLORO-3,10- DIBROMO-6,11- DIHYDRO- 5H-BENZO [5,6]CYCLOHEPTA [1,2-B]PYRIDIN-11-YL)- 1-PIPERIDINE

摘要

A process for producing compounds of formula (1.0) is disclosed. The compoun d of formula (1.0) is produced by: (1) separating the atropisomers of (2.0) to obtain the atropisomers (2.0A) and (2.0B); (2) heating the atropisomer of formula (2.0B) at a suitable temperature in a suitable solvent to obtain a mixture of atropisomers of formulas (2.0A) and (2.0B); (3) separating the atropisomers of formulas (2.0A) and (2.0B) of step (2); and (4) reducing the atropisomer of formula (2.0A) to obtain a compound of formula (1.0). Preferably, R1 is Br, R2 is Cl and R3 is Br. Also disclosed is the (+)- atropisomer of formula (2.0) wherein R1 is Br, R2 is Cl and R3 is Br.