CYCLIC PEPTIDES AND MEDICINAL USE THEREOF

摘要

Cyclic peptides represented by general formula (1) and having VLA-4 adhesion inhibitory activities, and the use thereof as remedies for allergic inflammations or hepatitis. In said formula, A and F represent each Cys, Asp. etc.; B represents Ala etc.; C represents Asp analog etc.; D represents Tyr etc.; E represents Leu etc.; G represents a disulfide or amide linkage; R1 represents hydrogen or acyl; and R2 represents hydrogen or alkyl. <IMAGE>