发明名称 |
AGGLOMERATE OF SPHERICAL POLYVALENT-METAL ALGINATE PARTICULATES, CONTROLLED-RELEASE PREPARATION COMPRISING DIFFICULTLY SOLUBLE DRUG SUPPORTED ON SAID AGGLOMERATE, AND PROCESSES FOR PRODUCING THE BOTH |
摘要 |
<p>A process for producing a controlled-release preparation capable of rapidly dissolving out at least 99 % of a difficultly soluble drug having a low dissolution rate above the small intestine, which process comprises supporting a difficultly soluble drug having a low intestinal dissolution rate on an agglomerate of spherical polyvalent-metal alginate particulates wherein the specific surface area of the secondary particle ranges from 1 to 280 m<2>/g.</p> |
申请公布号 |
EP0970705(A1) |
申请公布日期 |
2000.01.12 |
申请号 |
EP19980950454 |
申请日期 |
1998.10.29 |
申请人 |
FREUND INDUSTRIAL CO., LTD.;NISSHINBO INDUSTRIES, INC. |
发明人 |
HOM-MA, TAKESHI;MYO, NAGAYOSHI;SATO, TAKAYA;NANBU, HIRONOBU |
分类号 |
A61K9/14;A61K9/16;A61K47/36;C08L5/04;(IPC1-7):A61K47/36;C08B37/04 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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