发明名称 |
Tricyclic benzodiazepines |
摘要 |
Tricyclic benzodiazepine derivatives (A) bearing a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. A bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. A bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. A are useful as sedative, muscle relaxant and anti-convulsant agents.
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申请公布号 |
US3905956(A) |
申请公布日期 |
1975.09.16 |
申请号 |
US19700026068 |
申请日期 |
1970.04.06 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
DERIEG, MICHAEL EDWARD;EARLEY, JAMES VALENTINE;FRYER, RODNEY IAN;STERNBACH, LEO HENRYK |
分类号 |
C07D487/04;(IPC1-7):C07D487/04;C07D498/04 |
主分类号 |
C07D487/04 |
代理机构 |
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主权项 |
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