Butyryl cholinester inhibitors exhibiting high selectivity for treating and diagnosing Alzheimer's disease and dementia

摘要

A method for treating cognitive impairments associated with aging or Alzheimer's disease which comprises treating a patient at risk for having the cognitive impairment with an effective amount of a highly selective butyrylcholinesterase inhibitor which is N<8>-benzylnorcymserine, N<1>-phenethylnorcymserine, N<1>, N<8>-bisnorcymserine, N<1>-N<8>-bisbenzylnorphysostigmine, N<1>, N<8>-bisbenzylnorphenserine, N<1>, N<8>-bisbenzylnorcymserine, or pharmaceutical acceptable salts thereof.