| 摘要 |
PROBLEM TO BE SOLVED: To inexpensively and industrially obtain the subject compound important as a synthetic intermediate of an aminopyrimidine derivative useful as an insecticide, etc., in a new method and a high yield by chlorinating a specific raw material compound. SOLUTION: The objective compound is expressed by formula II and is obtained by chlorinating 5-chloro-6-(α-fluoroalkyl)-4-pyrimidone of formula I with a chlorination agent. Preferably, thionyl chloride, sulfuryl chloride, phosphorus oxychloride, phosphorus trichloride and phosphorus pentachloride is used as the chlorination agent. The chlorination agent may be used as 1-2 times mol to the compound of formula I. In a case of using thionyl chloride or sulfuryl chloride as the chlorination agent, an addition of N,N-dimethylformamide to a reaction system is required. Preferably, its using amount is >=0.3 wt.% to the compound of formula I. The reaction is preferably performed at 30-100 deg.C for usually 0.5-10 hrs.
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