| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new amido derivative having an excellent improving effect on a trouble caused by dyskeratosis of the skin. SOLUTION: This amido derivative is shown by formula I [R1 is a (substituted) 4-20C alkyl; R2 is a 1-7C alkyl; R3 is H or 2,3-dihydroxypropyl; R4 is a 2-4C alkylene] such as a compound of formula II. The compound of formula I is, for example, obtained by reacting an alcohol with epichlorohydrin in the presence of a phase transfer catalyst such as a quaternary ammonium salt or the like (e.g. tetrabutyl ammonium bromide or the like) and a base at preferably 20-80 deg.C for 1-12 hrs to form glycidyl ether, reacting the glycidyl ether with an amine derivative of formula H2N-R4 OCH3 at preferably 20-150 deg.C for 2-8 hrs to form an intermediate of formula III and reacting the resulting intermediate of formula III with an ester such as methyl propionate at preferably 15-100 deg.C for 2-8 hrs. Preferably, an external preparation contains 0.01-10 wt.% the above compound.
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