| 摘要 |
A time release dispenser of insect repellant and anchored to the stratum corneum, whereby the repellant cargo is dispensed over a period of time, and resists removal by perspiration, abrasion, or detergent wash. An example is a bipolar lipid membrane formed into liposome configuration, and caused to envelope and partition an organic molecule that normally has a very limited solubility in aqueous media. The organic molecule may be, for example, a mosquito repellant N, N-Diethyl-m-toluamide known by the acronym "DEET". Another example is an insecticide ar repellant for animals. The prior art liposomal delivery system depends upon forming liposomes in an aqueous media, thereby capturing some of the media in the core volume. In the preferred embodiment this invention, a burden of a substantially water insoluble substance is sequestered in a bipolar lipid bladder, which lipid and burden may be used as such or targeted to a designated site. Preferably, a target molecule, such as pyridinethione, is used to anchor the liposomal structure to the stratum corneum:
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