| 摘要 |
PROBLEM TO BE SOLVED: To produce a racemic carboxylic acid useful as a raw material for manufacture an optically active substance through an optical resolution method which is performed using a small amount of a regent with a simple operation, by mixing a specific optically active carboxylic acid with a specific sulfonyl chloride or the like and heating the mixture in the presence of a base. SOLUTION: (A) An optically active carboxylic acid in which a carboxyl group is bound to an asymmetric carbon [e.g. (R)-tetrahydrofuran-2-carboxylic acid] and (B) (i) a sulfonyl chloride of the formula R1-SO2Cl (R1 is a 1-12C alkyl which is not substituted or substituted with a 1-12C alkyl or the like, or the like) (e.g. benzenesulfonyl chloride) or (ii) a carbonyl chloride of the formula R1-COCl (e.g. benzoyl chloride) are mixed with each other, and the obtained mixture is heated in the presence of (C) a base such as triethylamine preferably at 50-150 deg.C to obtain the objective compound (e.g. tetrahydrofuran-2- carboxylic acid) having a lower optical activity than the component A.
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