METHOD OF STABILIZATION OF POLYPEPTIDE, AND METHODS OF PREPARING POLYPEPTIDE COMPOSITIONS

摘要

FIELD: medicine. SUBSTANCE: described are methods and compositions for stabilization of dry and aqueous forms of polypeptides treated with organic solvents. To this end, polypeptide is mixed with polyol which is trehalose and is then treated with organic solvent and encapsulated into polymeric matrix where polymer is polylactide. Method protects polyleptide from denaturation when treated with organic solvent. EFFECT: more efficient stabilization method. 31 cl, 4 ex, 8 tbl