发明名称 Incorporation of latent acid solubilizing agents in coated pellet formulations to obtain ph independent release
摘要 This invention is directed to a composition and method for the sustained delivery of an orally administered pharmaceutical agent where said agent has a pH dependent solubility profile. A pH independent release for drugs with pH dependent solubility is accomplished through the incorporation of a latent acid member with the pharmaceutical agent in the core of the tablet or pellet formulation which maintains the microenvironmental pH within and around the tablet or pellet in the solubility pH range of the pharmaceutical agent.
申请公布号 AU9023198(A) 申请公布日期 2000.01.10
申请号 AU19980090231 申请日期 1998.08.18
申请人 THERATECH, INC. 发明人 PHENIL J. PATEL;RAMESH ACHARYA;SIRISH C. DAVE
分类号 A61K9/16;A61K9/50 主分类号 A61K9/16
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