METHOD OF SYNTHESIS OF R-(+)-1,2,3,6-TETRAHYDRO-4-PHENYL-1- -[(3-PHENYL-3-CYCLOHEXENE-1-YL)METHYL]PYRIDINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS, INTERMEDIATE SUBSTANCES AND METHODS OF THEIR SYNTHESIS

摘要

FIELD: organic chemistry and chemical technology. SUBSTANCE: invention describes the improved 5-stage method of synthesis of R-(+)-1,2,3,6-tetra-hydro-4-phenyl-1-[(3-phenyl-3-cyclohexene-1-yl)methyl] -pyridine from 5-oxo-3-phenyl-3-cyclohexene carboxylic acid. Except for, invention describes methods of separation of seteroisomers of 5-oxo-3-phenyl-3-cyclohexene carboxylic acid using cinchonidine for synthesis of (S)-5-oxo-3-phenyl-3- -cyclohexene carboxylic acid or using alpha-chymotrypsin for selective hydrolysis of 5-oxo-3-phenyl-3-cyclohexene carboxylic acid n-butyl ester to obtain (S)-5-oxo-3-phenyl-3-cyclohexene carboxylic acid. Invention describes also other valuable intermediate compounds used in proposed methods of synthesis. Method is useful for large-scale synthesis. EFFECT: improved method of synthesis, decreased cost of the parent reagents. 39 cl, 2 ex