HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITION, METHOD OF PHARMACEUTICAL COMPOSITION PREPARING, INTERMEDIATE COMPOUNDS, METHODS OF SYNTHESIS OF HETEROCYCLIC DERIVATIVES

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel compounds of the formula (I) <EMI ID=0.1 HE=35 WI=104 TI=CHI>, their N-oxides, stereochemically isomeric forms and pharmaceutically acceptable acid-additive salts where A and B taken in common form bivalent radical of the formula: -N= CH- (a); -CH= N- (b); -CH= CH- (c); -CH2-CH2- (d); -C(=O)-CH2- (e); -CH2-C(= O)- (f); R1 means hydrogen atom, C1-6-alkyl or halogen atom; R2 means hydrogen or halogen atom; R3 means C1-8-alkyl, C3-6-cycloalkyl or C1-8-alkyl, substituted hydroxyl, oxo-group; Het means five- or six-membered heterocyclic ring. Invention describes the use of these compounds as drugs, in part, as agents used for decrease of lipids level and pharmaceutical compositions and methods of synthesis of compounds and compositions preparing. EFFECT: improved method of synthesis, valuable medicinal properties. 13 cl, 15 tbl, 11 ex