| 摘要 |
Methods of identifying agents that inhibit folding of beta (1,3)-glucan chains, comprising denaturing a beta (1,3)-glucan test sollution; contacting the denatured beta (1,3)-glucan test solution with an agent to be tested; maintaining the denatured beta (1,3)-glucan test solution under renaturing conditions; assessing the conformation of the beta (1,3)-glucan composition in the renatured beta (1,3)-glucan test solution; and comparing the conformation of the beta (1,3)-glucan composition in the renatured beta (1,3)-glucan test solution with the conformation of the beta (1,3)-glucan composition in a beta (1,3)-glucan control solution, are disclosed, as are agents identified by the methods, compositions comprising the agents, and methods of treating a fungal infection or a fungal growth by administering the agents or compositions. |
