摘要 |
The present invention is concerned with the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p represents 0, 1, 2 or 3; q represents 0, 1, 2, 3 or 4; R<SUP>1 </SUP>represents hydrogen, C<SUB>1-6</SUB>alkyl, mono- or di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyloxy, mercapto, C<SUB>1-6</SUB>alkylthio, C<SUB>3-7</SUB>cycloalkyl, aryl or C<SUB>1-6</SUB>alkyl substituted with mono- or di(C<SUB>1-6</SUB>alkyl)amino, C<SUB>1-6</SUB>alkyloxy, aryl or Het; R<SUP>2 </SUP>represents cyano or a radical of formula -C(-X)-Y-R<SUP>5</SUP>; wherein X represents O or S; Y represents O, S, NR<SUP>6 </SUP>or a direct bond; R<SUP>5 </SUP>represents hydrogen; C<SUB>3-7</SUB>cycloalkyl; aryl or optionally substituted C<SUB>1-6</SUB>alkyl; and where Y is a direct bond, R<SUP>5 </SUP>may also be halo or Het; R<SUP>3 </SUP>and R<SUP>4 </SUP>each independently represents halo, haloC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyl, hydroxy, C<SUB>1-6</SUB>alkyloxy, C<SUB>1-6</SUB>alkylcarbonyloxy, mercapto, C<SUB>1-6</SUB>alkylthio, C<SUB>1-6</SUB>alkylsulfonyl, C<SUB>1-6</SUB>alkylsulfinyl, haloC<SUB>1-6</SUB>alkylsulfonyl, aryl, cyano, nitro, amino, mono- and di(C<SUB>1-6</SUB>alkyl)amino or (C<SUB>1-6</SUB>alkylcarbonyl)amino; aryl represents phenyl or substituted phenyl; and Het represents an optionally substituted heterocycle; in the manufacture of a medicament useful for treating eosinophil-dependent inflammatory diseases. The invention also relates to novel compounds, their preparation and compositions comprising them. |