发明名称 |
Mutated herpes simplex virus type 1 thymidine kinases and uses thereof |
摘要 |
The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug. |
申请公布号 |
AU4582899(A) |
申请公布日期 |
2000.01.10 |
申请号 |
AU19990045828 |
申请日期 |
1999.06.22 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
RICHARD DRAKE;TRENTON HINDS;BARRY HURLBURT;CESAR COMPADRE;TAMMY RECHTIN |
分类号 |
A61K48/00;C12N9/12 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|