| 摘要 |
FIELD: organic chemistry, medicine, pharmacology. SUBSTANCE: invention proposes the novel agent for SUPPRESSION of skin or vagina atrophy. This agent acting by activation and/or SUPPRESSION of gene by raloxifen-estrogen receptor complex is the compound of the formula: <EMI ID=0.1 HE=35 WI=61 TI=CHI> where: R1 and R3 mean independently each of other hydrogen atom, methyl, <EMI ID=0.2 HE=12 WI=30 TI=CHI> or <EMI ID=0.3 HE=10 WI=10 TI=CHI> where Ar is optionally substituted phenyl; R2 is taken among the group including pyrrolidine, piperidine and hexamethyleneamine, or its pharmaceutically acceptable salts. EFFECT: enhanced effectiveness of the method. 4 cl, 18 comp
|
