| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel compound that is prepared by covalently bonding a benzonaphthacene quinone to a specific organic compound, thus has an antimicrobial activity of the benzonaphthacenequinones, can increase the solubility in water to attain efficient and selective transportation of medicines by introducing a chemical structure for controlling their physical and chemical properties and has high safety with side-effects reduced. SOLUTION: This novel compound is a benzonaphthacene quinone covalently bonded to a polyether or glycosaminoglycan represented by the formula (R1 is H, a lower alkyl or the like; R2 is a hydroxyl group, amino group or the like; R3 is H, a sulfated D-xylosyl or the like; R4 is H, D-xylosyl or the like), typically monodecyloxy-tetraethylene glycol-benanomicin A. The compound is prepared, for example, by protecting the hydroxyl groups in the compound of the formula, then allowing the carboxyl group in the compound of the formula to react with the amino groups or hydroxyl groups to form the acid amide bonds or ester bonds.
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