| 摘要 |
PROBLEM TO BE SOLVED: To obtain a compound used for modification of a compound or a drug with the purpose of the reduction of the antigenicity of the compound or the drug, the stabilization thereof, the extension of the residence time thereof in blood or the like by introducing a carboxyl group or an activated carboxyl group in the center of a triglycerin. SOLUTION: A carboxyl group-containing polyoxyalkylene compound is represented by the formula I, wherein R1 is a hydrogen atom, a 1-24C hydrocarbon group or a 1-24C acyl group; R2 is a 3-4C hydrocarbon group; R3 is a 1-10C hydrocarbon group; AO is a 3-4C oxyalkylene group; Y is a hydrogen atom or an active group represented by formula II or formula III; n is an average number by mol of addition of an oxyethylene group which is 1-1,000; m is an average number by mol of addition of a 3-4C oxyalkylene group which is 0-250; n/(n+m) is not less than 0.8; and the oxyethylene group and the 3-4C oxyalkylene group may be added in a block or in a random order.
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