| 摘要 |
<p>A process is disclosed for the preparation of an imidazolone and the pharmaceutically acceptable salts thereof having formula (1). The process comprises treating an α-acylaminonitrile of formula (2) with an organic or inorganic acid having the formula HA in a nonaqueous solvent and in the presence of an alcohol of the formula R-OH where R is C5 to C12 alkyl, C5 to C12 alkenyl, C3 to C12 cycloalkyl, poly alkylene ether, poly alkylene thio ether or aryl either unsubstituted or substituted with at least one C1 to C6 alkyl, C1 to C6 alkoxy or halo.</p> |
