MODULARLY CONSTRUCTED RNA MOLECULES HAVING TWO SEQUENCE REGION TYPES

摘要

The invention relates to modularly constructed RNA molecules which can bind to a ligand and which are characterized by two sequence regions. Said first sequence region contributes to the maintenance of the three-dimensional structure of the RNA molecule, and a second sequence region is responsible for the specific bond of the ligand. These RNA molecules, e.g. the NINTROX-RNA, can be used for directly influencing the gene expression. The invention also relates to vectors containing the inventive RNA molecules, to medicaments and diagnostic compositions which contain said RNA molecules or vectors, to an antibody which specifically recognizes these RNA molecules or antisense RNA which specifically binds to these RNA molecules, or to ribozymes which split these RNA molecules. In addition, the invention relates to non-human mammals whose NINTROX gene is modified by inserting a heterologous sequence and to the cells obtained therefrom.