发明名称 |
USE OF POXVIRUSES AS ENHANCER OF SPECIFIC IMMUNITY |
摘要 |
The invention relates to a method for enhancing the specific immune response against an immunogenic compound which comprises administering the immunogeni c compound together with a poxvirus recombinant and a vaccinal antigen, which is not a poxvirus. The immunological material may be any biological material useful as a vaccine e.g., a polypeptide characteristic of a pathogenic microorganism or associated with a tumoral disorder, a DNA plasmid encoding a peptide or a polypeptide characteristic of a pathogenic microorganism or a tumor-associated antigen, or an hapten coupled to a carrier molecule. The poxvirus may be a live, attenuated or inactivated virus or a recombinant virus. Recombinant virus may encode a heterologous polypeptide such as chemokines, cytokines or co-immunostimulatory molecules or an homologous polypeptide, which is immunologically cross reactive with the immunogenic polypeptide or peptide. |
申请公布号 |
CA2335508(A1) |
申请公布日期 |
2000.01.06 |
申请号 |
CA19992335508 |
申请日期 |
1999.06.28 |
申请人 |
AVENTIS PASTEUR |
发明人 |
SAMBHARA, SURYAPRAKASH;MOSTE, CATHERINE;MEIGNIER, BERNARD;CHEVALIER, MICHEL |
分类号 |
A61K35/76;A61K39/00;A61K39/145;A61K39/21;A61K39/39;A61P31/00;A61P35/00;A61P37/02;C12N7/01 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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