发明名称 |
Oligonucleotides for enhanced modulation of protein kinase c expression |
摘要 |
Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides are from 5 to 50 nucleotides in length and in one referred embodiment are from 12 to 18 nucleotides in length. The oligonucleotides may be chimeric oligonucleotides and in a preferred embodiment comprise at least one 2'-O-methoxyethyl modification. Pharmaceutical compositions comprising the oligonucleotides of the invention are also provided. Methods of inhibiting protein kinase C expression and methods of treating conditions associated with expression of protein kinase C using oligonucleotides of the invention are disclosed. |
申请公布号 |
AU4684099(A) |
申请公布日期 |
2000.01.05 |
申请号 |
AU19990046840 |
申请日期 |
1999.06.15 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
C. FRANK BENNETT;NICHOLAS M DEAN |
分类号 |
A61K38/00;C12N9/12;C12N15/113;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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