| 摘要 |
1317256 Nitrofuran and nitrothiophene derivatives LILLY INDUSTRIES Ltd 6 July 1970 [15 July 1969 20 April 1970] 35593/69 and 18801/70 Heading C2C Novel compounds of Formula I (in which Y is O or S, n is 0 or 1, R is H or C 1-6 alkyl, and each of R<SP>1</SP> and R<SP>11</SP> is H, C 1-6 alkyl, hydroxy-C 1-6 alkyl or C 1-6 alkoxy-C 1-6 alkyl, or R<SP>1</SP> and R<SP>11</SP>, together with the adjacent nitrogen atom, form a heterocyclic ring having 5 to 7 ring atoms, up to 2 of which are hetero atoms selected from N, O and S atoms, and the remainder of which are C atoms, said ring being optionally substituted by one or more C 1-6 alkyl, hydroxy-C 1-6 alkyl or OH substitutes, and any sulphur atom being optionally oxidized) are prepared by reacting a compound of Formula II with a compound of formula H 2 N.NR<SP>1</SP>R<SP>11</SP>. Pharmaceutical compositions having antitrypanosomal activity, for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier. |
