发明名称 |
Stabilization of fibroblast growth factors by modification of cysteine residues |
摘要 |
The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.
|
申请公布号 |
US6010999(A) |
申请公布日期 |
2000.01.04 |
申请号 |
US19950459906 |
申请日期 |
1995.06.02 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
DALEY, MICHAEL JOSEPH;BUCKWALTER, BRIAN LEE;CADY, SUSAN MANCINI;SHIEH, HONG-MING;BOHLEN, PETER;SEDDON, ANDREW P. |
分类号 |
A61K47/48;C07K14/50;(IPC1-7):A01N61/00;A01N37/18 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|