发明名称 |
RECONSTITUTED HUMAN ANTIBODY AGAINST HUMAN INTERLEUKIN 6 RECEPTOR. |
摘要 |
<p>A reconstituted human antibody against a human interleukin 6 receptor (IL-6R), which is composed of: (A) an L chain composed of (1) the C region of a human L chain and (2) the V region of an L chain comprising the framework region (FR) of a human L chain and the complementarity-determining region (CDR) of the L chain of a mouse monoclonal antibody against a human IL-6R, and (B) an H chain composed of (1) the C region of a human H chain and (2) the V region of an H chain comprising the FR of a human H chain and the CDR of the H chain of a mouse monoclonal antibody against a human IL-6R. Since most of the reconstituted human antibody originates in human antibodies and the CDR is lowly antigenic, this antibody is lowly antigenic against human and hence prospective as a therapeutic agent. <IMAGE></p> |
申请公布号 |
GR3031174(T3) |
申请公布日期 |
1999.12.31 |
申请号 |
GR19990402267T |
申请日期 |
1999.09.08 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TSUCHIYA, MASAYUKI;SATO, KOH;BENDIG, MARY, MARGARET;JONES, STEVEN, TARRAN;SALDANHA, JOSE, WILLIAM |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P35/00;C07K16/18;C07K16/24;C07K16/26;C07K16/28;C07K19/00;C12N5/10;C12N15/13;C12P21/08;C12R1/91;G01N33/53;G01N33/577;(IPC1-7):C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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