NEW COMPOUNDS FOR DNA-TRANSFECTION

摘要

The invention relates to conjugates of lipids and basic, modified membrane disturbing peptides, characterized in that the peptides comprises a reversed amide backbone, particularly compounds of formula (I), wherein R<1> and R<2> are a hydrocarbyl moiety of a straight-chain or branched-chain, saturated or unsaturated aliphatic carboxylic acid or a phospholipid moiety, R<3> is a basic, modified membrane disturbing peptide with a reversed amide backbone, Y is C2-10 alkylene, X is -C(O)-NH- or -S-S-, and salts thereof.