EXPANDED BED ADSORPTION SYSTEM

摘要

The present application describes various improvements and further developments to the Expanded Bed Adsorption (EBA) technology. In particular, the application describes an EBA process where elution is performed in fluidised mode, i.e. in expanded bed mode, the so-called All Expanded Process. This improvement which is based on the use of controlled density particles, e.g. particles having a density of at least 1.3 g/ml, provides valuable advantages with respect to use of reduced amounts of elution buffer. The application also describes the use of magnetic stirring in EBA columns, design of an inlet ring with multiple openings, outlet at the bottom or side an EBA column for the discharge of gel, mobile pipe outlet, floating outlet, temperature regulator at inlet, the use of coloured gel, the use of sensors, processes for the regeneration of buffer in EBA systems, the introduction of baffles, and disposable columns (single use sterile columns).