| 摘要 |
A compound is provided having formula (I) wherein: R1 and R2 are independent ly hydrogen, hydroxy, alkoxy or acyloxy; R3 and R4 are independently oxo, hydro xy or hydrogen; one of R5 or R6 is A-B and the other is hydrogen, hydroxy, alkoxy, acyloxy, a group -A-B or a group -amino-R7-O-Y; the or each A is independently a spacer group having the formula -amino-R7-O- which is bonded to the anthracene ring via the amino group nitrogen and to B via the -O-atom ; R7 is a divalent organic radical; B is an amino acid residue, a peptide grou p, or isostere thereof; and Y is hydrogen or a capping group, or a physiologically acceptable derivative thereof. The compounds primarily have utility against cancers, but also have use against viruses and parasites having topoisomerases.
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