NUCLEIC ACID-COBALAMIN COMPLEXES AND THEIR USE IN GENE THERAPY

摘要

Disclosed is a complex used to deliver nucleic acid to cells. In particular, disclosed are compositions and methods which use a nucleic acid encoding at least one protein, which nucleic acid is complexed with cobalamin. These compositions and methods utilize cobalamin receptor-mediated endocytosis for introduction of the protein-coding nucleic acid into cells. The compositions and methods allow for lower doses of nucleic acid to be used and reduce undesirable immunogenic effects.