发明名称 |
RECOGNITION OF PROTEIN CODING REGIONS IN GENOMIC DNA SEQUENCES |
摘要 |
A coding sensor using a recurrent neural network technique is provided. The coding sensor indicates the coding potential of a gene sequence and plays a vital role in the overall prediction of the gene structure. The recognition of the potential coding regions in a DNA sequence may be achieved by determining whether each individual nucleotide position in a nucleotide chain is in a coding region. Determining whether an individual nucleotide position is in a coding region may be accomplished through a systematic sampling process carried out along the nucleotide chain from start to end. The content variables of neighboring nucleotide positions are processed using a trained recurrent neural network in order to provide a coding sensor value. In this way, transition characteristics may be used to assist the coding sensor in determining whether a nucleotide position is in a coding region. The coding sensor value represents a prediction of whether or not the nucleotide position is in a coding region. Coding sensor values for each nucleotide position in the DNA sequence are aligned with the overall DNA sequence to generate a coding/non-coding picture of the DNA sequence. |
申请公布号 |
WO9966302(A2) |
申请公布日期 |
1999.12.23 |
申请号 |
WO1999US13705 |
申请日期 |
1999.06.17 |
申请人 |
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT;LOU, YUANDAN;ZHANG, ZHEN |
发明人 |
LOU, YUANDAN;ZHANG, ZHEN |
分类号 |
C12N15/10;C12Q1/68;G06F19/22;G06F19/24 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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