| 摘要 |
The present invention is concerned with new compounds of formula (I) wherein R1 is hydrogen, C1-6-alkyl, optionally substituted by fluoro, or C3-6- cycloalkyl; R2 is hydrogen or a group selected from -CH2C(=CHR)-COOR, - CH2OCOR, -CH(R)OCOR, -CH(R)OCOOR, -CH(OCOR)OCOR, -CH2COCH2OCOR and (II); R3 is hydrogen or group selected from -CH2C(=CH2)-COOR, -COOCH2C(=CHR)-COOR, - COOCH2OCOR, -COOCH(R)OCOR, -CO CH(R)OCOOR, -COOCH(OCOR)OCOR, -COOCH2COCH2OCO R, and (III); with the proviso that one of R2 and R3 is hydrogen and the other of R2 and R3 is different from hydrogen, R is hydrogen or C1-6-alkyl; R4 is hydrogen or hydroxy, R5 is hydrogen or .omega.-hydroxyalkyl; and X is CH or N, as well as pharmaceutically acceptable salts of said compounds and hydrates of said compounds and of their salts, and with the use of compounds of formula (I) and of pharmaceutically acceptable salts of said compounds and hydrates of said compounds and of their salts for the manufacture of pharmaceutical preparations containing such compounds. |
