New derivatives of 19-norandrostane useful in fertility control or treatment of e.g. endometriosis, mammary carcinoma or hypogonadism

摘要

19-Norandostrane derivatives of formula (I) are new. 19-Norandostrane derivatives of formula (I) are new: R1 = H or 1-9C alkyl; R2 = H or Me; R3, R4 = H, OH, OCOR5, OCONHR6, OSO2NR7R8, CH2R9 or SR10; or R3 + R4 = an oxo group; or CR3R4 = a spirooxirane group or a 2,2-dimethyl-1,3-dioxolane group; R5 = a group containing 1-10C atoms; R6 = H, 1-5C alkyl or 1-5C aryl (sic); R7, R8 = H or 1-5C alkyl; R7 + R8 = pyrrolidino, piperidino or morpholino; R9 = OH, 1-5C alkoxy, Cl, Br, N3, CN or a thiocyano group; R10 = 1-5C alkyl An Independent claim is included for preparation of (I)