| 摘要 |
<p>A screening method for selecting a substance having an effect of potentiating the expression of Pax4 gene in pancreatic β cells which is useful in protecting pancreatic β cells in an exhausted state or accelerating the function of pancreatic β cells. The substance obtained by the above screening method and/or activin receptor activator exhibit effects of potentiating the expression of Pax4 gene and accelerating the expression of insulin gene. Owing to these effects, the above substances are highly useful in medicinal compositions for preventing the progress of a disease caused by the exhaustion of pancreatic β cells (i.e., diabetes) and treating this disease.</p> |
