TRIAZOLO-PYRIMIDINES AS LIGANDS FOR GABA RECEPTORS

摘要

A class of substituted or 6,7-ring fused 1,2,3-triazolo[1,5-a]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the alpha 2 and/or alpha 3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.