PROCESS TO MANUFACTURE SIMVASTATIN AND INTERMEDIATES
摘要
A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
申请公布号
WO9965892(A1)
申请公布日期
1999.12.23
申请号
WO1999CA00540
申请日期
1999.06.10
申请人
APOTEX INC.;KARIMIAN, KHASHAYAR;TAM, TIM, FAT;TAO, YONG;LI, YIWEI;DOUCETTE, GARY
发明人
KARIMIAN, KHASHAYAR;TAM, TIM, FAT;TAO, YONG;LI, YIWEI;DOUCETTE, GARY