发明名称 |
METHOD FOR SEPARATION ON CATION EXCHANGERS |
摘要 |
A process for separation of a compound from a solution by cation exchange. O ne characterizing feature is that cation exchanger used carries a number of ligands X-Y(Z)n and requires an elevated ionic strength for elution a bound compound compared to standard cation exchangers. In the ligand a) X is -O-, - S(R1)- or -N(R1)(R2)-; b) Y may be: 1) a 5 or 6 membered cyclic structure containing dou ble bonds, preferably an aromatic group, or 2) an alicyclic C 5- C6 group or an aliphatic, straight or branched, C1-C3 group with the possibility that the chain joining X with Z may be interrupted by 1 or 2 eth er oxygen or thioether sulphur atoms and with the proviso that X is not -O- or -S- ; c) Z is cation exchanging group with a negative total charge or a protonat ed form thereof; and d) n is an integer > 0. The method is further character ized in that the binding is taking place at a pH at which the ligand has a net charge. |
申请公布号 |
CA2334980(A1) |
申请公布日期 |
1999.12.23 |
申请号 |
CA19992334980 |
申请日期 |
1999.06.16 |
申请人 |
AMERSHAM PHARMACIA BIOTECH AB |
发明人 |
BERGSTROM, JAN;BERGLUND, ROLF;SODERBERG, LENNART |
分类号 |
B01J39/04;B01J39/18;B01J45/00 |
主分类号 |
B01J39/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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