Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake

摘要

This invention provides compounds of Formula I: <CHEM> where A-B is -C=CH- or -CHCH2-; n is 0 or 1; R<1> is H or C1-C4 alkyl; R<2> is H, methyl, or ethyl; and Aryl is naphthyl or heteroaryl, each optionally monosubstituted with a substitutent selected from the group consisting of H, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, cyano, nitro, carboxamido, and trifluoromethyl; or pharmaceutically acceptable salts or hydrates thereof, provided that when n is 1, A-B is -CHCH2-; and a method for the inhibition of serotonin reuptake in mammals.