发明名称 |
Chemical compounds |
摘要 |
The invention provides a gene construct encoding a cell targeting moiety and a heterologous prodrug activating enzyme for use as a medicament in a mammalian host where in the gene construct is capable of expressing the cell targeting moiety and enzyme as a conjugate within a target cell in the mammalian host and wherein the conjugate is directed to leave the cell thereafter for selective localisation at a cell surface antigen recognised by the cell targeting moiety.
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申请公布号 |
GB2338484(A) |
申请公布日期 |
1999.12.22 |
申请号 |
GB19990022815 |
申请日期 |
1998.05.05 |
申请人 |
* ZENECA LIMITED |
发明人 |
STEPHEN CHARLES * EMERY;DAVID CHARLES * BLAKEY |
分类号 |
C12N15/09;A61K31/17;A61K31/198;A61K31/711;A61K35/76;A61K38/00;A61K38/46;A61K39/395;A61K47/48;A61K48/00;A61P35/00;A61P43/00;C07K16/28;C07K16/30;C12N9/48;C12N15/52;C12N15/62;C12N15/63;C12P21/08;C12R1/91;(IPC1-7):C12N15/62 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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