发明名称 |
Phenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them |
摘要 |
Compounds of the formula where T is and R(A), R(B), R(C), R(D), R(E), R(F), x and y have the meanings indicated in the claims, and their pharmaceutically acceptable salts are effective inhibitors of the cellular sodium-proton antiporter (Na+/H+ exchanger). These compounds are therefore outstandingly suitable for treatment of all illnesses which are to be attributed to increased Na+/H+ exchange.
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申请公布号 |
US6005010(A) |
申请公布日期 |
1999.12.21 |
申请号 |
US19970915329 |
申请日期 |
1997.08.20 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
SCHWARK, JAN-ROBERT;BRENDEL, JOACHIM;KLEEMANN, HEINZ-WERNER;LANG, HANS JOCHEN;WEICHERT, ANDREAS;JANSEN, HANS-WILLI;SCHOLZ, WOLFGANG |
分类号 |
C07D213/65;A01N1/00;A61K31/155;A61K31/165;A61K31/44;A61K31/4406;A61P3/06;A61P9/00;A61P9/06;A61P9/10;A61P13/02;A61P15/00;A61P25/00;A61P43/00;C07C277/08;C07C279/20;C07C279/22;(IPC1-7):A61K31/165 |
主分类号 |
C07D213/65 |
代理机构 |
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代理人 |
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地址 |
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