| 发明名称 |
Pyrone derivatives as protease inhibitors and antiviral agents |
| 摘要 |
The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
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| 申请公布号 |
US6005103(A) |
申请公布日期 |
1999.12.21 |
| 申请号 |
US19940319769 |
申请日期 |
1994.10.12 |
| 申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
DOMAGALA, JOHN MICHAEL;LUNNEY, ELIZABETH;PARA, KIMBERLY SUZANNE;PRASAD, JOSYULA VENKATA NAGENDRA VARA;TAIT, BRADLEY DEAN |
| 分类号 |
A61K31/365;A61P31/12;A61P31/18;C07D309/38;C07D335/02;C07D403/06;C07D405/04;C07D405/06;C07D405/10;C07D405/12;C07D407/04;C07D407/12;C07D409/04;C07D413/12;C07F7/18;(IPC1-7):C07D309/00;C07D319/00;C07D409/00;C07D405/00 |
主分类号 |
A61K31/365 |
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