发明名称 |
Method of inhibiting transcription utilizing nuclear receptors |
摘要 |
This invention provides a method of inhibiting the transcription of a gene, which is activated by AP-1 or an AP-1 component, comprising binding AP-1 or the component with a nuclear receptor so as to prevent the binding of AP-1 to the gene. The nuclear receptor can be the retinoic acid receptor, glucocorticoid receptor, vitamin D3 receptor, thyroid receptor, or estrogen receptor. Also provided is a composition of matter comprising AP-1 or an AP-1 component bound to a nuclear receptor. These methods and compositions can be used to treat arthritis and cancer.
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申请公布号 |
US6004748(A) |
申请公布日期 |
1999.12.21 |
申请号 |
US19960757349 |
申请日期 |
1996.11.27 |
申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION |
发明人 |
PFAHL, MAGNUS;KARIN, MICHAEL |
分类号 |
A61K38/00;C07K14/705;C07K14/82;C12N15/67;G01N33/566;G01N33/68;(IPC1-7):C12Q1/68;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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