Universal allyl linker for solid-phase nucleic acid synthesis

摘要

A universal linker for solid-phase nucleic acid synthesis that is cleaved under conditions orthogonal to those used during the synthesis and deprotection of nucleic acids such as dsDNA or RNA fragments is disclosed. The invention includes compounds of the formula: wherein R1 is selected from the group consisting of OH, OR2 and an amino functionalized support and n is an integer ranging from about 1 to about 1000 or more preferably from about 1 to about 100 or greater and R2 is an alkyl (C1-20) or greater.