N-PHOSPHONYLMETHOXYALKYL PYRIMIDINES AND PURINES AND THERAPEUTIC APPLICATION THEREOF

摘要

Disclosed are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from such heterocyclic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Most of the compounds exhibit a marked antiviral activity against DNA-viruses and can be used in therapeutic antiviral compositions.