| 摘要 |
The present invention relates to tricyclic carbapenem antibacterial agents wherein X is CH2, CHRa, CHRb, C=CHRa, C=CHRb, O, S, SO, SO2, CO, COO<OCO, NRa, NRb; and Z is trans-ethenediyl or ethynediyl. The compound is further substituted with various substituent groups including at least one cationic group.The compounds are represented by formula I:Pharmaceutical compositions and methods of use are also included. |
