DERIVATIVES OR DI- OR TRIAZA SPIRO[4,5]DECANE, METHOD OF OBTAINING THEM AND THERAPEUTIC AGENTS CONTAINING SUCH COMPOUNDS

摘要

The present invention relates to compounds of the general formula wherein R<1> is C6-10-cycloalkyl, optionally substituted by lower alkyl or -C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicycloÄ6.2.0Üdec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl; R<2> is hydrogen; lower alkyl; =O or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; A &cir& is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; X is -CH(OH)-; -C(O)-; -CHR<3>-; -CR<3>=; -O-; -S-; -CH(COOR<4>)- or - C(COOR<4>)=; Y is -CH2-; -CH=; -CH(COOR<4>)-, -C(COOR<4>)=; or -C(CN)-; R<3> is hydrogen or lower alkoxy; R<4> is lower alkyl, cycloalkyl, phenyl, or benzyl and either a or b is optionally an additional bond, and to pharmaceutically acceptable acid addition salts thereof. The compounds are agonists and/or antagonists of the orphanin FQ (QFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.