Aromatic amine derivatives as pharmaceutical agents

摘要

Aromatic amines of formula (1) are described: wherein Az is an optionally substituted monocyclic six-membered nitrogen-containing aromatic group; L1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; and R5 is a group -L2(CH2)tR6 in which L2 is a -N(R7)CO- or -N(R7)CS- group. The compounds are able to inhibit the binding of alpha 4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.